* In patients using Jivi on-demand [n=1086] and for prophylaxis [n=764]
* 20 patients aged 13-61 years underwent 26 major surgeries, 21 of which were orthopedic surgeries (one hip replacement, 10 knee replacements and three ankle replacements, two open synovectomies, four arthroscopic procedures, and one knee/thigh hematoma evacuation), three were complex dental extractions, and two were other procedures (penile prosthesis and inguinal hernia repair). In the study, the surgeon was asked to compare the outcome with expected blood loss in patients without hemophilia undergoing comparable procedures using a four-point scale: Excellent – blood loss less than expected; Good – blood loss as expected; Moderate – blood loss more than expected; Poor – uncontrolled bleeding. Of the 26 major surgeries, 17 were assessed as Good and nine were assessed as Excellent.2
† Includes preoperative and any intraoperative infusions on the day of surgery until 0h of the following day.2
‡ 8 of 26 major surgeries required one infusion and 3 of 26 major surgeries required zero infusions.2
§ Median dose administered on day of surgery: 77.57 [42.9-136.4] IU/kg.2